| 1st Qualifying Round | 2nd Qualifying Round | 3rd Qualifying Round | Play-offs | Group Stage | Round of 16 |
| Quarterfinals | Semifinals | Final |
Round:
Played
1st Round
09/15/2021 - Wednesday
12:45
Sheriff
2
x
0
Shakhtar Donetsk
15:00
Internazionale
0
x
1
Real Madrid
2nd Round
09/28/2021 - Tuesday
12:45
Shakhtar Donetsk
0
x
0
Internazionale
15:00
Real Madrid
1
x
2
Sheriff
3rd Round
10/19/2021 - Tuesday
15:00
Internazionale
3
x
1
Sheriff
15:00
Shakhtar Donetsk
0
x
5
Real Madrid
4th Round
11/03/2021 - Wednesday
13:45
Real Madrid
2
x
1
Shakhtar Donetsk
16:00
Sheriff
1
x
3
Internazionale
5th Round
11/24/2021 - Wednesday
12:45
Internazionale
2
x
0
Shakhtar Donetsk
15:00
Sheriff
0
x
3
Real Madrid
6th Round
12/07/2021 - Tuesday
15:00
Real Madrid
2
x
0
Internazionale
15:00
Shakhtar Donetsk
1
x
1
Sheriff