| 1st Qualifying Round | 2nd Qualifying Round | 3rd Qualifying Round | Play-offs | Group Stage | Round of 16 |
| Quarterfinals | Semifinals | Final |
Round:
Played
1st Round
09/14/2021 - Tuesday
12:45
Young Boys
2
x
1
Manchester United
15:00
Villarreal
2
x
2
Atalanta
2nd Round
09/29/2021 - Wednesday
12:45
Atalanta
1
x
0
Young Boys
15:00
Manchester United
2
x
1
Villarreal
3rd Round
10/20/2021 - Wednesday
15:00
Manchester United
3
x
2
Atalanta
15:00
Young Boys
1
x
4
Villarreal
4th Round
11/02/2021 - Tuesday
16:00
Atalanta
2
x
2
Manchester United
16:00
Villarreal
2
x
0
Young Boys
5th Round
11/23/2021 - Tuesday
12:45
Villarreal
0
x
2
Manchester United
15:00
Young Boys
3
x
3
Atalanta
6th Round
12/08/2021 - Wednesday
15:00
Manchester United
1
x
1
Young Boys
12/09/2021 - Thursday
13:00
Atalanta
2
x
3
Villarreal