| 1a Fase | 2a Fase | 3a Fase | Fase de Grupos | Oitavas | Quartas |
| Semi | Final |
Round:
Played
1st Round
04/05/2022 - Tuesday
15:15
Colón
2
x
1
Peñarol
15:15
Olimpia
0
x
0
Cerro Porteño
2nd Round
04/12/2022 - Tuesday
15:15
Cerro Porteño
3
x
1
Colón
17:30
Peñarol
2
x
1
Olimpia
3rd Round
04/27/2022 - Wednesday
17:00
Cerro Porteño
1
x
0
Peñarol
04/28/2022 - Thursday
17:00
Olimpia
0
x
0
Colón
4th Round
05/04/2022 - Wednesday
15:00
Colón
2
x
1
Cerro Porteño
17:00
Olimpia
1
x
0
Peñarol
5th Round
05/17/2022 - Tuesday
15:15
Peñarol
0
x
0
Cerro Porteño
05/18/2022 - Wednesday
17:00
Colón
2
x
1
Olimpia
6th Round
05/25/2022 - Wednesday
17:00
Cerro Porteño
0
x
1
Olimpia
17:00
Peñarol
2
x
1
Colón