| 1a Fase | Fase de Grupos | Oitavas | Quartas | Semi | Final |
Round:
Played
1st Round
08/10/2021 - Tuesday
18:15
Rosario Central
3
x
4
Bragantino-SP
08/11/2021 - Wednesday
18:15
Sporting Cristal
1
x
3
Peñarol
08/12/2021 - Thursday
18:15
LDU
1
x
0
Atlético-PR
20:30
Santos-SP
2
x
1
Libertad
2nd Round
08/17/2021 - Tuesday
18:15
Bragantino-SP
1
x
0
Rosario Central
08/18/2021 - Wednesday
18:15
Peñarol
1
x
0
Sporting Cristal
08/19/2021 - Thursday
18:15
Atlético-PR
4
x
2
LDU
20:30
Libertad
1
x
0
Santos-SP