| 1a Fase | 2a Fase | 3a Fase | Fase de Grupos | Oitavas de Final | Quartas de Final |
| Semifinal | Final |
Round:
Played
1st Round
02/27/2018 - Tuesday
17:15
Defensor Sporting
1
x
1
Grêmio-RS
17:15
Monagas
0
x
2
Cerro Porteño
2nd Round
03/13/2018 - Tuesday
20:30
Cerro Porteño
2
x
1
Defensor Sporting
04/04/2018 - Wednesday
18:15
Grêmio-RS
4
x
0
Monagas
3rd Round
04/17/2018 - Tuesday
18:15
Defensor Sporting
3
x
1
Monagas
20:30
Cerro Porteño
0
x
0
Grêmio-RS
4th Round
04/25/2018 - Wednesday
20:45
Monagas
1
x
0
Defensor Sporting
05/01/2018 - Tuesday
18:15
Grêmio-RS
5
x
0
Cerro Porteño
5th Round
05/15/2018 - Tuesday
18:15
Defensor Sporting
0
x
1
Cerro Porteño
20:30
Monagas
1
x
2
Grêmio-RS
6th Round
05/23/2018 - Wednesday
18:15
Cerro Porteño
3
x
2
Monagas
18:15
Grêmio-RS
1
x
0
Defensor Sporting