| 1a Fase | 2a Fase | 3a Fase | Fase de Grupos | Oitavas de Final | Quartas de Final |
| Semifinais | Final |
Round:
Played
1st Round
04/06/2021 - Tuesday
20:30
San Lorenzo
1
x
3
Santos-SP
04/07/2021 - Wednesday
20:30
Libertad
1
x
0
Atlético Nacional
04/08/2021 - Thursday
20:30
Bolivar
2
x
1
Junior Barranquilla
04/09/2021 - Friday
18:15
Independiente del Valle
2
x
1
Grêmio-RS
2nd Round
04/13/2021 - Tuesday
20:30
Santos-SP
2
x
2
San Lorenzo
04/14/2021 - Wednesday
18:15
Grêmio-RS
1
x
2
Independiente del Valle
20:30
Atlético Nacional
4
x
1
Libertad
04/15/2021 - Thursday
20:30
Junior Barranquilla
3
x
0
Bolivar