| 1a Fase | 2a Fase | 3a Fase | Fase de Grupos | Oitavas de Final | Quartas de Final |
| Semifinais | Final |
Round:
Played
1st Round
08/10/2021 - Tuesday
20:30
São Paulo-SP
1
x
1
Palmeiras-SP
08/11/2021 - Wednesday
18:15
Olimpia
1
x
4
Flamengo-RJ
20:30
River Plate
0
x
1
Atlético-MG
08/12/2021 - Thursday
20:30
Fluminense-RJ
2
x
2
Barcelona de Guayaquil
2nd Round
08/17/2021 - Tuesday
20:30
Palmeiras-SP
3
x
0
São Paulo-SP
08/18/2021 - Wednesday
18:15
Flamengo-RJ
5
x
1
Olimpia
20:30
Atlético-MG
3
x
0
River Plate
08/19/2021 - Thursday
20:30
Barcelona de Guayaquil
1
x
1
Fluminense-RJ