| 1a Fase | 2a Fase | 3a Fase | Fase de Grupos | Oitavas de Final | Quartas de Final |
| Semifinais | Final |
Round:
Played
1st Round
04/20/2021 - Tuesday
18:15
Always Ready
2
x
0
Internacional-RS
18:15
Deportivo Tachira
3
x
2
Olimpia
2nd Round
04/27/2021 - Tuesday
20:30
Internacional-RS
4
x
0
Deportivo Tachira
04/28/2021 - Wednesday
22:00
Olimpia
2
x
1
Always Ready
3rd Round
05/05/2021 - Wednesday
20:00
Internacional-RS
6
x
1
Olimpia
05/06/2021 - Thursday
18:00
Always Ready
2
x
0
Deportivo Tachira
4th Round
05/11/2021 - Tuesday
18:15
Deportivo Tachira
2
x
1
Internacional-RS
05/13/2021 - Thursday
20:00
Always Ready
1
x
2
Olimpia
5th Round
05/19/2021 - Wednesday
22:00
Deportivo Tachira
7
x
2
Always Ready
05/20/2021 - Thursday
20:00
Olimpia
0
x
1
Internacional-RS
6th Round
05/26/2021 - Wednesday
18:00
Internacional-RS
0
x
0
Always Ready
18:00
Olimpia
6
x
2
Deportivo Tachira