| 1a Fase | 2a Fase | 3a Fase | Fase de Grupos | Oitavas de Final | Quartas de Final |
| Semifinais | Final |
Round:
Played
1st Round
04/22/2021 - Thursday
18:00
Fluminense-RJ
1
x
1
River Plate
22:00
Junior Barranquilla
1
x
1
Santa Fe
2nd Round
04/28/2021 - Wednesday
20:00
River Plate
2
x
1
Junior Barranquilla
20:00
Santa Fe
1
x
2
Fluminense-RJ
3rd Round
05/06/2021 - Thursday
20:00
Junior Barranquilla
1
x
1
Fluminense-RJ
20:00
Santa Fe
0
x
0
River Plate
4th Round
05/12/2021 - Wednesday
20:00
Fluminense-RJ
2
x
1
Santa Fe
20:00
Junior Barranquilla
1
x
1
River Plate
5th Round
05/18/2021 - Tuesday
20:30
Fluminense-RJ
1
x
2
Junior Barranquilla
05/19/2021 - Wednesday
20:00
River Plate
2
x
1
Santa Fe
6th Round
05/25/2021 - Tuesday
18:15
River Plate
1
x
3
Fluminense-RJ
18:15
Santa Fe
0
x
0
Junior Barranquilla