| 1a Fase | 2a Fase | 3a Fase | Fase de Grupos | Oitavas de Final | Quartas de Final |
| Semifinais | Final |
Round:
Played
1st Round
04/21/2021 - Wednesday
18:00
La Guaira
1
x
1
Atlético-MG
22:00
América de Cali
0
x
2
Cerro Porteño
2nd Round
04/27/2021 - Tuesday
18:15
Atlético-MG
2
x
1
América de Cali
04/28/2021 - Wednesday
18:00
Cerro Porteño
0
x
0
La Guaira
3rd Round
05/04/2021 - Tuesday
18:15
Atlético-MG
4
x
0
Cerro Porteño
05/06/2021 - Thursday
22:00
La Guaira
0
x
0
América de Cali
4th Round
05/12/2021 - Wednesday
20:00
La Guaira
0
x
1
Cerro Porteño
05/13/2021 - Thursday
20:00
América de Cali
1
x
3
Atlético-MG
5th Round
05/19/2021 - Wednesday
20:00
Cerro Porteño
0
x
1
Atlético-MG
22:00
América de Cali
3
x
1
La Guaira
6th Round
05/25/2021 - Tuesday
20:30
Atlético-MG
4
x
0
La Guaira
20:30
Cerro Porteño
1
x
0
América de Cali