| 1a Fase | 2a Fase | 3a Fase | Fase de Grupos | Oitavas de Final | Quartas de Final |
| Semifinais | Final |
Round:
Played
4th Round
05/12/2021 - Wednesday
23:00
Atlético Nacional
0
x
0
Nacional-URU
05/13/2021 - Thursday
18:00
Vélez Sarsfield
3
x
1
LDU
20:00
Always Ready
1
x
2
Olimpia
20:00
América de Cali
1
x
3
Atlético-MG
5th Round
05/18/2021 - Tuesday
18:15
Nacional-URU
1
x
0
Universidad Católica
18:15
Palmeiras-SP
3
x
4
Defensa y Justicia
18:15
The Strongest
2
x
1
Santos-SP
20:30
Fluminense-RJ
1
x
2
Junior Barranquilla
20:30
São Paulo-SP
0
x
1
Racing Club
20:30
Universitario
3
x
2
Independiente del Valle
05/19/2021 - Wednesday
18:00
Sporting Cristal
2
x
0
Rentistas
18:00
Vélez Sarsfield
2
x
1
Unión La Calera
20:00
Cerro Porteño
0
x
1
Atlético-MG
20:00
Flamengo-RJ
2
x
2
LDU
20:00
River Plate
2
x
1
Santa Fe
22:00
América de Cali
3
x
1
La Guaira
22:00
Deportivo Tachira
7
x
2
Always Ready
05/20/2021 - Thursday
18:00
Argentinos Juniors
1
x
0
Atlético Nacional
20:00
Boca Juniors
0
x
0
Barcelona de Guayaquil
20:00
Olimpia
0
x
1
Internacional-RS
6th Round
05/25/2021 - Tuesday
18:15
River Plate
1
x
3
Fluminense-RJ
18:15
Santa Fe
0
x
0
Junior Barranquilla
20:30
Atlético-MG
4
x
0
La Guaira
20:30
Cerro Porteño
1
x
0
América de Cali
20:30
Racing Club
3
x
0
Rentistas
20:30
São Paulo-SP
3
x
0
Sporting Cristal
05/26/2021 - Wednesday
18:00
Internacional-RS
0
x
0
Always Ready
18:00
Olimpia
6
x
2
Deportivo Tachira
20:00
Barcelona de Guayaquil
3
x
1
Santos-SP
20:00
Boca Juniors
3
x
0
The Strongest